Combination effect of silymarin, quercetin, and hesperidin on anxiety and depression in 3 nitropropionic acid-induced rat model of huntington’s disease

Huntington’s disease is an autosomal-dominant, progressive neurodegenerative disorder with chorea, incoordination, cognitive decline, and behavioral difficulties, whereas bioflavonoids have the potential to promote anxiety depression. The aim of this study was investigate summarize synergistic effect silymarin, quercetin, hesperidin on depression in 3-nitropropionic acid (3-NP)-induced rat model disease. We divided animals into eight groups (n = 6) for different combination treatment said along 3-NP. Anxiety such as symptoms were assessed 21st day post-treatment elevated plus maze, light, dark force swim test. Dopamine serotonin level brain striatum also measured after completion analysis these neurotransmitters are involved like behavior. found that intraperitoneal administration 3-NP (10 mg/kg B/W) 21 days leads male Wistar rats, combinations ameliorate symptoms. At end study, we concluded more effective ameliorating compared mono therapy.